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KMID : 0378020080510110033
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New Medical Journal
2008 Volume.51 No. 11 p.33 ~ p.37
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Changes of Regional Cerebral Blood Flow after Olfactory Stimulation in Normal Volunteers: Tc-99m-ECD Brain SPECT
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Kim Ki-Jun
Chung Yong-An
Lee Sang-Hoon
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Abstract
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Background: The purpose of this study was to investigate olfactory function according to Tc-99m ECD uptake pattern in brain perfusion single photon emission computed tomography (SPECT) of normal volunteer by means of statistical parametric mapping (SPM) analysis.
Materials and Methods: The study populations were 7 subjects matched healthy volunteers (M : F = 6:1, Ages: 22-54 years, mean 34 years). We performed baseline brain perfusion SPECT using 555 MBq of Tc-99m ECD at the silent dark room. At the 2 hours later, we obtained brain perfusion SPECT using 1110 MBq of Tc-99m ECD after 3% butanol
solution under the same condition. All of the SPECT images were spatially transformed to standard space smoothed and globally normalized. The differences between the baseline and odor-stimulation SPECT images were statistically analyzed using SPM-99 software. The difference between two sets of brain perfusion SPECT was considered significant at a threshold of uncorrected P values less than 0.01.
Results: SPM analysis revealed significantly hyperperfusion in the both cingulated gyri, the right middle temporal gyrus, the right superior & inferior frontal gyri, the right lingual gyrus and the right fusiform gyrus on odor-stimulation SPECT
Conclusions: The brain perfusion SPECT can securely support other diagnostic techniques in the evaluation of olfactory function. Moreover, this study would be helpful in the research of diverse smell disorder.
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KEYWORD
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Tc-99m ECD, Olfactory stimuli, Statistical parametric mapping
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